I have gone back and forth for years. Years ago, I decided that I would put all of my signed cards in toploaders. When I started the project, it was easy to do as I only had a few 1000 signed cards. After a while, I found I was buying cases and cases of toploaders just to keep up with the demand. I also consider the bulk of my autographs to be lower end, so protection was not as desired as consistency. Plus, oversized cards like 54-56 Topps and such would then fit in as well. Then the manufacturers started doing sealed cases (uncirculated), so those would need to be removed and re-sleeved in toploaders to match, and I was not willing to do that. Finally, I had enough of the expense of toploaders and pulled ALL signed cards and now they sit in sleeves whether its a $1 TTM or a $300 certified auto.
Ideally, I'd like them in 9 pocket pages within albums, but that would cost a fortune and I am always adding to the collection. That would never work.
My Garvey cards all go in some sort of toploader or rigid case. Since there are sealed cases, thick cards and such, they will never all be in the same holders though.
I'm sure I'll change my mind again in the future...